There will be not be issues that are handled at creating universe.

Things to be taken care by designer  are

1. Avoid un-necessary import of tables from schemas to the universe.
2. In case  of loops based on the requirements analyse and proper usage of Aliases and Contexts to be used.
3. Proper usage of @Aggregate_Aware function for measure objects.
4. Creation of conditional objects based on specifications.
5. Proper usage of joins and set cardinalities.
6. Need to parse objects and conditions created.